Effect of Auricularia Polytricha Sacc Polysaccharide on PKA Activity in Murine Peritoneal Macrophages
- VernacularTitle:毛木耳多糖对小鼠腹腔巨噬细胞蛋白激酶 A活性的影响
- Author:
Daofu WANG
;
Lingping SHAO
;
Baowen JU
;
Wang DING
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(5):263-264
- CountryChina
- Language:Chinese
-
Abstract:
AIM： To investigate the effect of Auricularia Polytricha Sacc Polysaccharide（ APSP） on protein kinase A（ PKA） activity in murine peritoneal macrophages METHODS： New ion－ pair RP－ HPLC method was used to determinate the activity of PKA in murine peritoneal macrophages RESULTS： APSP（ 80mg/L） induced activation of PKA in murine peritoneal macrop_ hages； the peak appeared at 8 minutes and the activity of PKA returned to the basic level at 20 minutes CONCLUSION： The immunopoteniating effect of APSP may be associated with its activating effect on PKA in murine peritoneal macrophages
