Distribution and Pharmacokinetics of Lung Targeting Etoposide－ bovine Serum Albumin－ microspheres in Mice
- VernacularTitle:依托泊苷白蛋白微球小鼠体内分布及药代动力学
- Author:
Zhiqing ZHANG
;
Xiuling YANG
;
Li SUN
;
Sumin LI
;
Shumei WANG
;
Chuanping WANG
;
Jianming LEI
;
Dehou FAN
;
Junkang JIANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(5):265-266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To prepare etoposide－ bovine serum albumin－ microspheres (VP－ BSA－ MS)and to study the distribution and pharmacokinetics of VP－ BSA－ MS in mice. METHODS: The drug concentrations in various tissues were determined by high－ performance liquid chromatograph (HPLC). RESULTS: The VP－ BSA－ MS was injected into mice and (47.88± 2.56 )％ of the total dosage was detected in lung tissue 15min after administration， the pharmacokinetical equation was C=149.0 897e－ 1.7 780t＋ 3.9 627e－ 0.0 398t — 153.0 524e－ 3.5 054t. CONCLUSION： The VP－ BSA－ MS showed remakable targeting action to the lung and the pharmacokinetic regularity could be discribed as two－ compartment model
