Inhibitory effect of scopolamine on withdrawal syndromes in morphine dependent rats
- VernacularTitle:不同方法使用东莨菪碱脱毒效果的比较
- Author:
Qiang FU
;
Xinhua WANG
;
Xueyin SHI
;
Yang LU
;
Jinglan TANG
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(4):351-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the inhibitory effect of scopolamine(Spm) and chlopromazine (Clo) on withdrawal syndromes in morphine dependent rats. Methods: The intensity of withdrawal syndromes on the model of morphine dependent rats was recorded after single or muiltiple subcutaneous administration(sc) of Spm and Clo at different doses. Results: Withdrawal syndromes were markedly decreased when single Spm 1 mg/kg and Clo 0.5 mg/kg combined with morphine were injected (P<0.05). Spm+Clo(sc) had much stronger effects on inhibiting withdrawal syndromes after intraperitoneal (ip) naloxone in morphine dependent rats (P<0.01). Conclusion: Spm can act on Ach-receptor and relieve morphine withdrawal syndromes. Clo may have a synergistic action with Spm via α2-receptor in the locus coeruleus of the rat brain stem.
