Expressions of protein kinase C subtypes in glomerulonephritis and their significance
- VernacularTitle:蛋白激酶亚型在肾小球肾炎中的表达及意义
- Author:
Bingmin XIAO
;
Miaozhen ZHU
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(4):454-456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and significance of protein kinase C (PKC) subtype α, β2 and ε in the pathogenesis of glomerulonephritis. Methods Immunohistochemical assays was used to examine the expressions of PKC α, PKC β2 and PKC ε in biopsy specimens of kidney from patients with mesangial proliferative glomerulonephritis (MsPGN) （n=16），nonproliferative golmerulonephritis (nonPGN) (n=12)，and in structurally normal kidneys (n=6). Results The PKC β2 expression in the glomerular was significantly higher in MsPGN patients than in nonPGN or normal kidney groups. Conclusion PKC β2 has a close association with MsPGN and might take part in the initiation of this renal disease.
