The effect of brain-derived neurotrophic factor on regeneration of nerve fibers after crush injury

VernacularTitle:脑来源神经生长因子对坐骨神经捻挫损伤后再生的作用
Author: Qiuyue HE ; Manfu HAN
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2001;5(5):51-52
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the effect of brain derived neurotrophic factor(BDNF) on regeneration of distal axon in sciatic nerve after cfrush injury. MethodDistal axon was assessed by quantitavtive and qualitative analysis of pathology ResultLight microscope indicated thedensity of large diameter of peroneal-nerve was higher in study group compared with control group( P ＜0.01 ). No differences in density of littlediameter fiber were found between study and control group. EM showed the density of non-medullated fibers with diameter ＜0.5μm in studygroup was higher than that of control group. The numbers of layer in myelin was positively related to transverse axonal area( P ＜0.01 ) . The re-gression codfficient in study group wsa higher compared with control group( P = 0. 0023).ConclusionBDNF may promoted maturation ofsensoy nerve and formation of the myeline.