STUDY ON THE STRUCTURE AND ACTIVITY OF NEW PHENOLIC ACID COMPOUNDS FROM ERIGERON BREVISCAPUS
- VernacularTitle:灯盏花中新的酚酸类化合物的结构及活性研究
- Author:
Weidong ZHANG
;
Wansheng CHEN
;
Fouraste ISABELLA
;
Deyun KONG
;
Huiting LI
;
Yonghong WANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(5):360-363
- CountryChina
- Language:Chinese
-
Abstract:
AIM To isolate and identify the active constituents of Erigeron brevisapus (Vant.) Hand. -Mazz. METHODS The chemical constituents were isolated by silica gel column chromatography and two new compounds were obtained. Their structures were elucidated by IR, MS, 1HNMR, 13CNMR, DEPT and 2DNMR. The injury of BCMEC (bovine cerebral microvascular endothelial cell) was determined by lactic dehydrogenase (LDH), the ability of the drugs anti-oxidation and scavenging oxidation of free radical was measured by colorimetric method. RESULTS Two new compounds have been identified as 1-O-methyl-3, 5-O-dicaffeoyl quinic acid methyl ester (III) and 5-O-caffeoyl quinic acid butyl ester (IV). CONCLUSION Compounds III and IV are new compounds. Compound III can protect BCMEC injury by LPC.
