Time-related effects of danazol treatment in experimentally induced endometriosis in the rat
- VernacularTitle:丹那唑治疗大鼠子宫内膜异位症的时间相关作用
- Author:
Hui ZHENG
;
Sicun HE
;
Zhiquan BAI
;
Zuoyan ZHOU
;
Zineng WANG
;
Hongyi LI
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(5):422-424
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS:The purpose of the study was to characterize the time-related effect of Danazol therapy on endometriosis explant using the rat model. Endometriosis was induced in mature female rats. One group of treated animals as well as controls were sacrificed at 2,4,6 and 8 weeks after treatment at which time the explant was evaluated. RESULTS:Explant volume was significantly reduced in all treatment groups, and the effect was more significant in animals treated for 4 weeks than those treated for only 2 weeks. CONCLUSION:Danazol treatment can cause gradual regression of endometrial explant in a time-related manner.
