Effects of esculentoside A on production of IL-1 and TNF by rabbit synovial cells
- VernacularTitle:商陆皂苷甲对兔滑膜细胞产生IL-1和TNF的影响
- Author:
Qinyue ZHENG
;
Huifeng WANG
;
Xiangmin ZHENG
;
Zhenyu XIAO
;
Yanghua YI
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(5):425-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the influence of esculentoside A（EsA） on production of IL-1 and TNF by rabbit synovial cells induced by LPS. Methods: levels of IL-1 and TNF in the supernatant of rabbit synovial cell were determined by examining proliferation of thymic cells and by bioassay L929 cells as target cells, respectively. Results: EsA in 5-40 μg/ml could significantly inhibit the production of IL-1 and TNF from rabbit synovial cells induced by LPS. Conclusion: EsA can inhibit the production of IL-1 and TNF from synovial cells. It suggests that EsA may play a role in improving the rheumatoid arthritis.
