Effect of nucleus pulposus autograft to the cavum epidurale on the structure and function of nerve roots in rats
- VernacularTitle:硬膜外移植自体髓核对大鼠神经根结构和功能的影响
- Author:
Shisheng HE
;
Tiesheng HOU
;
Xiaowei SHAN
;
Jianwen WANG
;
Jinhui XIA
;
Ji WANG
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(5):435-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To find out the pathomechanism of low back and leg pain related to intervertebral disc. Methods: The nucleus pulposus of coccygeal vertebral was transplanted to the cavum epidurale of rats to establish the non-compressive model with transplanted nucleus pulposus. The evoke potentials and morphology of nerve roots were observed. Results: Even without mechanical compression, rats transplanted with nucleus pulposus resulted in significant harm to evoked potential and morphology of cauda equina. Conclusion: The biomechanical and/or immunologic inflammatory effect of nucleus pulposus can result in nerve roots injury and is an important factor in the pathogenesis of low back and leg pain.
