Expression of p73 gene in human non-small cell lung cancer i n vitro
- VernacularTitle:p73基因在人非小细胞肺癌组织中的表达
- Author:
Yong HE
;
Zhiping LI
;
Shizhi FAN
;
Yaoguang JIANG
;
Jianming CHEN
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(5):536-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of p73 in human non-small cell lung cancer (NSCLC) and the relationship between p73 expression and clinico-pathological parameters. Methods Expression of p7 3 gene was detected by RT-PCR in 32 human NSCLC tissues, tissues adjacent to ca ncer and non-cancer lung tissues. Results p73 gene expression up-regulated substantially and detected in 87.5%(28/32) of human NSCLC tissues while expressed at low level in tissues adjacent to cancer and non-cancer lung tissues. Conclusion Marked up-regulation of p73 gene expres sion is found in human NSCLC.
