Experimental study on preventive and therapeutic effec ts of 5 radioprotectants on combined radiation-burn injured mice
- VernacularTitle:E838等5种辐射防护药对放烧复合伤防治作用的实验观察
- Author:
Chaohua GUO
;
Peiyan KONG
;
Zhongmin ZOU
;
Yanhong ZHOU
;
Jinming ZHOU
;
Yong ZHANG
;
Cunmeng SHI
;
Xinze RAN
;
Chengji LUO
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(5):544-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the irradiation-protective and inter-synergestic effects of E838,WR-2721, Rubia cordifolia, cystamin e hydrochloride and ethinyl estradiol on radiation and combined radiation-burn injury. Methods Above-mentioned drugs were given to the mice i ntraperitoneally, or intragastrcally, then, the mortality and the average surviv al d for 30 d were observed before and after the administration of the drug s. Results ①When drugs were before injury , the survival rate and the average survival d of the radiation and combined radiation-burn injured mice were increased obviously with the best effect in E838 and WR-2721. ②When drugs were given after injury, E838 and R. cordifolia also kept the effect. ③Combined appling WR-2721（pre) and E838（post）displayed a significant syner gistic reaction. Conclusion E838 and WR-2721 are more e ffective than the others in the prevention of radiation.
