Determination of telomerase activity in carcinoma of bile duct and its clinical significance
- VernacularTitle:胆管癌组织端粒酶活性检测及意义
- Author:
Xiaodong GU
;
Kuansheng MA
;
Zhenping HE
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(5):582-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between te lomerase activity and bile duct carcinoma and its significance in clinical diag nosis. Methods Telomerase activities were examined in 23 cases of bile duct carcinoma, 5 cases of carcinoma adjacent tissues and 5 cases of nor mal bile duct tissues respectively with telomerase PCR-ELISA method. Results Telomerase activity was detected in 18 of 23 cases (78.3%) of b ile duct carcinoma, and was not found in 5 cases of carcinoma adjacent tissues a nd 5 cases of normal bile duct tissues. The detection rate of telomerase activit y had no correlation with patients' age, sex, tumor site and size but significan tly correlated to metastasis of tumor (P<0.05). Conclusion The level of telomerase activity was significantly higher in bile duct carcino ma and may be served as one of the clinical marker for malignant neoplasm becaus e of its spsecificity.
