RCT on the therapautical effect of mospride citrate in functional dyspe psia
- VernacularTitle:口服莫沙必利治疗功能性消化不良的随机对照试验
- Author:
Siping DA
;
Xiaoyan ZHAO
;
Yihui LI
;
Hongyuan SU
;
Juyou DENG
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(5):593-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the curative effect and sid e effect of the gastrokinetic agent mosapride citrate by RCT. Methods 42 cases of functional dyspepsia (FD) were divided into two groups rando mly, the group of mosapride(21 cases):orally administrated mosapride, 5mg, t.i.d for 4 weeks, and the control (21 cases):orally administrated domperidone, 5mg, t.i.d for 4 weeks. Symptoms and side effects were recorded before and at d 14, d 28 after administration of the medicines according to GCP and double blind pri ciple. Gastric empting test was also carried out in randomly selected patients. Results Mosapride and domperidone were significantly effective on alleviating symptoms of the patient with FD. In mosapride treated group the half emptying time was shortened and the 120 min remain rate was reduced. No sid e effect was found. Conclusion These results suggest that mosa pride 5 mg t.i.d. is effective and safe on alleviating symptoms of patients with FD and improving the ga stric empting time.
