Nitrasotion of Astemizole Followed by Its Determination Using Single-sweep Oscillopolarography
- VernacularTitle:单扫描示波极谱法测定阿司咪唑
- Author:
Bin LIU
;
Wenxia WANG
;
Wei GUO
;
Junfeng SONG
- Publication Type:Journal Article
- From:
Chinese Journal of Analytical Chemistry
2001;29(6):703-706
- CountryChina
- Language:Chinese
-
Abstract:
Astemizole is nitrasoted with sodium nitrite in 0.12 mo l/L HAc solution at boiling bath for 25 min. The nitrosation product of astemizo le shows a reduction peak by single-sweep oscillopolarography. The peak potenti al is -0.72V (vs.Ag/AgCl). The first-order derivative peak current is propo rtional to the concentration of astemizole in the range of 4.0×10-7～1.6 ×10-5 mol/L (r=0.9997), with detection limit of 2.0×10-7 mol/L . The proposed method has been applied to the determination of astemizole in pha rmaceutical tablets.
