Tne effect of nitric oxide and its inhibitor on secondary spinal cord injury
- VernacularTitle:一氧化氮在脊髓损伤中改善血供与加重损伤的双重相关性研究
- Author:
Xiuhui WANG
;
Ziping WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2001;5(6):40-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of NO on secondary spinal cord injury. Method L - arginine{L - Arg} and N - nitric-Larginine methylester{L - NAME} were infused into subarachnoid space of rats 30 min before spinal cord injury(SCI) . Spinal cord blood flow (SCBF) at trauma sites was monitored. After SCI by a Laser - Doppler flowmetry and neurological function was evaluated. Result The result showed that L - arg increased SCBF at trauma sites, but exaggerated the SCI. The proper dose of L - NAME decreased early SCBF at trauma sites, but ameliorated neural function. Large dose of L - NAME restricted NO production for a long time and resulted in spinal cord isehemia, thus exacerbating SCI. Conclusion That over - production or over - restriction of NO worsen SCI.
