The damages of adrenal gland in rabbits with neisseria memingococcal septic shock
- VernacularTitle:家兔脑膜炎双球菌感染性休克的肾上腺病变
- Author:
Kaihe DU
;
Guoqing YIN
;
Bei ZHONG
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(6):566-568
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the damages of adrenal gland in rabbits infected with neisseria meningococci(MC).METHODS: 18 rabbits were injected with MC (1×1011 organism/kg, iv, model group, n=10) or normal saline (control group, n=8).TNF-α was detected in baseline (before challenged), 60 min and 120 min after injection. 120 min after injection, TNF-α immunochemical localization of adrenal gland was detected with ABC methods by electron microscopy. RESULTS: In model group, TNF-α positive cells were located in medulla and TNF-α released into simus of medulla. The medulla damages were appeared but gland cells of cortex was normal. No damages were showed in control group. TNF-α value of plasm was elevated at 60 min and 120 min after injection compared with control group. CONCLUSION: TNF-α was released into medulla and resulted in medulla damages after MC challenging. Adrenal cortex didnt damaged in early phase of MC septic shock.
