Effect of matrix metalloproteinase and its inhibitor in the formation of abdominal aortic aneurysms
- VernacularTitle:基质金属蛋白酶及其抑制剂在腹主动脉瘤发病中的作用
- Author:
Jianqiu WU
;
Zaiping JING
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(6):580-583
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular matrix plays an important role in maintaining organic structure and function, cellular proliferation and differentiation of normal aorta. Extracellular matrix proteolysis and remodeling of aortic wall resulting from degradation of matrix proteins characterize abdominal aortic aneurysm (AAA). Matrix metalloproteinase and its inhibitor have been implicated as potentially important in this disease, and MMP/TIMP ratios may be the key of AAA formation and development.
