Chemokine receptors in regulating immune response and therapy
- VernacularTitle:趋化因子受体对免疫应答的调节及其治疗意义
- Author:
Tao ZHANG
;
Bingzhong SUN
;
Boquan JIN
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(6):584-588
- CountryChina
- Language:Chinese
-
Abstract:
Although adhesion molecules have long been recognized to be differentially expressed on naive and effector/memory T cells,it has recently been found that a number of chemokine receptors are also differentially expressed on T cells,depending on their Ag experience and type of polarization. Recent data suggests that chemokines and their receptors are essential elements that regulate the positioning of T cells and their partners for priming and T helper 1 (Th1)- or Th2-mediated responses,therefore,are probably the most promising targets for treating immune diseases.
