A Case-Control Study on Association Between Hepatocellular Carcinoma and Infection of Hepatitis B and Hepatitis C Virus.
- Author:
Hyeong Sik AHN
1
;
Min Ho KIM
;
Young Sick KIM
;
Joung Soom KIM
Author Information
1. Department of Preventive Medicine, College of Medicine, Korea University, Korea.
- Publication Type:Original Article
- Keywords:
Hepatocellular Carcinoma;
Odd Ratio;
Hepatitis B surface antigen;
Hepatitis B core antibody;
Hepatitis C antibody
- MeSH:
Carcinoma, Hepatocellular*;
Case-Control Studies*;
Hepacivirus*;
Hepatitis B Surface Antigens;
Hepatitis B*;
Hepatitis C*;
Hepatitis*;
Humans
- From:Korean Journal of Preventive Medicine
1997;30(1):1-16
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To investigate the association between hepatocellular carcinoma(HCC) and infection of hepatitis B virus(HBV) and hepatitis C virus(HCV) in an HBV endemic area , a case-control study of 254 patients with HCC and of 1,270 age and sex matched health control subjects was done. Among the 254 HCC patients 166(65.4%) were positive for hepatitis B surface antigen(HBsAg), 49(19.3%) were positive for HCV antibody(anti-HCV Ab). The crude odd ratio of patients with HBsAg was 36.1(95% CI :22.4-58.2) and with anti-HCV Ab was 9.0(95% CI :5.5-14.6). In an analysis, which HBsAg(-), HBcAb(-), anti-HCV Ab(-) group was chosen as referent group, odd ratio of HBsAg(+) group was 14.4(95% CI: 7.2-28.9) and of anti- HCV Ab(+) was 10.7(95% CI: 2.9-40.0). Odd ratio of anti-HCV Ab(+), HBsAg(+) group and anti-HCV Ab(+), HBsAg(-), HBcAb(+) group for HCC were elevated to 27.3(95% CI : 9.0-82.9) , 15.9(95% CI:7.1-35.8) respectly. The odd ratio of anti-HCV Ab(-), HBsAg(-), HBcAb(+) group was 2.4(95% CI : 1.1-5.0). These result suggested that HBV and HCV were associated with HCC. In HBV endemic area patients with HBcAb alone should be considered risk group for HCC.
