The Changes of Insoluble Particles of Shuanghuanglian in Quantity After Mixed With Three Different Drugs
- VernacularTitle:双黄连与 3种不同药物配伍前、后微粒的变化
- Author:
Yanmin CHEN
;
Jianhua ZHOU
;
Kaiyu JIANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(6):378-379
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the changes of insoluble particles of shuanghuanglian in quantity after mixed with benzylpenicillin,cefradine and dexamethasone in normal saline.METHODS: Using ZWF-4D particle counter,the number of insoluble particles in sizes of ≥ 2.0μ m,≥ 5.0μ m,≥ 10.0μ m and ≥ 25.0μ m was counted and compared before and after mixed with above-mentioned three drugs.RESULTS: The insoluble particles of Shuanghuanglian were obviously increased after mixed with benzylpenicillin,the particles in sizes of ≥ 5.0μ m,≥ 10.0μ m and ≥ 25.0μ m increased twice,23 and 94 times respectively.The insoluble particles were also increased after mixed with cefradine or dexamethasone,however,the increase rate was lower in comparison with that mixed with benzylpenicillin.CONCLUSION: Shuanghuanglian,used in combination with above-mentioned drugs,should be put into separate infusion bottle to avoid the increase of insoluble particles and ADRs.