Effects of N-methyl-D-aspartate on the cochlear potentials

VernacularTitle:N-甲基-D-天冬氨酸对豚鼠耳蜗内电位的影响
Author: Lan ZHANG ; Jinhui XIA ; Mingfang DIAO ; Wenyuan GAO
Publication Type:Journal Article
From: Academic Journal of Second Military Medical University 2001;22(12):1126-1129
CountryChina
Language:Chinese
Abstract: Objective: To study the effects of TNFα on wound healing. Methods: The skin lesion and incisions were made on mice and rhTNFα was applied in both skin lesion and incision. Tissue strips were evaluated for tensiometry and histologic features after healing. Results: It was found that rhTNFα markedly improved wound healing both in skin lesion and incision wound model, it also markedly enhanced the breaking strength of treated incision and increased wound cellularity in rh TNF α treated groups. Conclusion: The results suggest that TNFα play an important role in regulating inflammatory reactions of local injured tissues and it may improve the functions of fibroblasts, mononuclear phagocytes and endothelial cells. rhTNFα of suitable doses can promote wound healing. This shows that TNFα, as a wound healing promoter, has the potentials for clinical application.