Effects of whole body irradiation with X-rays on the expression of TfR on lymphocytes in spleens of mice

Author: Can LUO ; Shibo FU ; Guizhi JU
Publication Type:Journal Article
Keywords: TfR; splenocytes; ionizing radiation
From: Journal of Jilin University(Medicine Edition) 2002;28(1):1-5
CountryChina
Language:Chinese
Abstract: Objective: To explore effect of TfR on immune function after ionizing by investigating changes in TfR expression on splenic lymphocytes of mice after whole body irradiation (WBI) with different dose X-rays. Methods: Direct immunoflurescence antibodies and flow cytometry were used to examine the changes of TfR expression. Results: The cell number of TfR positive expression in spleens increased significantly at 24 hours and 72 hours after WBI with 75 mGy X-rays but the cell number of TfR positive expression in spleens decreased significantly at 24 hours after WBI with 1～6 Gy X-rays. The activity of IL-2, meanwhile, demonstrated a parallel change. Conclusion: These results suggest that the TfR enhances immune function in low dose ionizing radiation but suppresses immune function in high dose. The change of TfR expression may be due to the change of IL-2 activity caused by ionizing radiation.