Transport of aripiprazole across Caco-2 monolayer model
- VernacularTitle:阿立哌唑在Caco-2细胞单层模型中的跨膜转运
- Author:
Juan WU
;
Xianyi SHA
;
Xiaoling FANG
- Publication Type:Journal Article
- Keywords:
aripiprazole;
Caco-2 cell;
transport;
P-glycoprotein
- From:
Acta Pharmaceutica Sinica
2009;44(2):188-191
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to investigate the transport characteristics of aripiprazole.A human intestinal epithelial cell model Caco-2 cell in vitro cultured had been applied to study the transport of aripiprazole.The effects of time,concentration of donor solutions,pH,temperature and P-glycoprotein inhibitor on the transport of aripiprazole were investigated.The determination of aripiprazole was performed by HPLC.It is concluded that aripiprazole is transported through the intestinal mucosa via a passive diffusion mechanism primarily,coex- isting with a carrier-mediated transport.The transport of aripiprazole is positively correlated to transport time, concentrations.The P-glycoprotein inhibitor cyclosporine A significantly enhanced the transport amount of aripiprazole.
