Experimental study on expression of TNF-α and ICAM-1 in cerebral ischemia-reperfusion injury
- VernacularTitle:肿瘤坏死因子-α和细胞粘附分子-1在脑缺血再灌注损伤中的表达规律
- Author:
Lili ZHANG
;
Jingzhou WANG
;
Huadong ZHOU
;
Mane CHEN
- Publication Type:Journal Article
- Keywords:
TNF-α;
ICAM-1;
cerebral ischemia reperfusion;
leukocytes
- From:
Chinese Journal of Tissue Engineering Research
2002;6(19):2968-2969
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of TNF α and ICAM 1 in cerebral ischemia reperfusion injury. To explore their probable modulation mechanism.Methods Immunohistochemistry was used to examine the expression of TNF α and ICAM 1.The MPO activity was determined by spectrophotometry.Result The expression of TNF α and ICAM 1 were obviously rised after cerebral ischemia reperfusion (P< 0.05).Conclusion The up regulation of TNF α and ICAM 1 after cerebral ischemia reperfusion induced the accumulation of leukocytes, which involved in ischemia reperfusion injury mechanism. TNF α play an important role in expression of ICAM 1.
