Relation of plasma homocysteine with folic acid and vitamine B12 in patients with cerebral infarction
- VernacularTitle:同型半胱氨酸、叶酸及维生素 B12水平与脑梗死发病的危险相关性
- Author:
Shunchang HAN
;
Yang GUO
;
Guijun SUN
;
Yueyu GU
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
homocysteine;
folic acid;
Vitamin B12
- From:
Chinese Journal of Tissue Engineering Research
2002;6(19):2970-2971
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship of cerebral infarction with hyperhomocysteinemia and the relationship between hyperhomocysteinemia and folic acid and Vitamine B12.Method We measured the concentrations of homocysteine with FIPA(fluorescence polarization immunoassay)and Vitamin B12 and folic acid with chemiluminescent competitive immunoassay in 40 cerebral infarction patients and 30 healthy controls.Results The concentration of homocysteine in study group was higher than the controls' (P< 0.01).Serum folic acid level in study group was lower than that in control group (P< 0.05).There is negative correlation between plasma homocysteine and serum folic acid(P< 0.05). Conclusions Hyperhomocysteinemia is an independent risk factor of atherosclerotic cerebral infarction.One reason of increased level of homocysteine in blood is that the deficiency of cofactors of enzymes involved in metabolism process.
