Effects of matrine on structure and function of K562 cells
- VernacularTitle:中药苦参碱对K562细胞骨架结构与功能的影响
- Author:
Yan ZHANG
;
Xiaoshan LIU
;
Yujuan HE
;
Lingdi MA
;
Xiangru XU
;
Jikai JIANG
- Publication Type:Journal Article
- Keywords:
natrine;
genes;
k562 cells
- From:
Chinese Journal of Tissue Engineering Research
2003;7(20):2788-2789
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of matrine on cytoskeletonof K562 cells. Methods Micropipette aspiration technique was adoptedto investigate the viscoelasticity of K562 cells, while the different ex-pression of cytoskeletal protein gene was analyzed by DNA microar-ray. Results In matrine-treated K562 cells, the viscoelastic propertiesKI, K2 and were decreased significantly from 726 ± 215 to 432 ±67,433 ±119 to 242±31, 72±38 to 50±15 respectively, and the geneexpression of prefoldin and ezrin was much stronger than that of controlcells. Conclusion The strueture and function can be changed in ma-trine-treated K562 cells.
