Evaluation of the short-term biocompatibility of a new kind of hydrogel prosthetic nucleus
- VernacularTitle:新型水凝胶人工髓核的短期生物相容性评价
- Author:
Jingping WU
;
Tongyi CHEN
;
Zhongwei CHEN
;
Zhewei HUANG
;
Guozhen GU
;
Hua LU
;
Aiying MENG
;
Yunfang QIAN
;
Yagu LI
- Publication Type:Journal Article
- Keywords:
implants,experimental;
intervertebral disk;
artificialorgans;
biocompatible materials
- From:
Chinese Journal of Tissue Engineering Research
2003;7(20):2778-2780
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate the short-term biocompatibility of a newkind of prosthetic nucleus-Evergel, which is made from the modifiedpolyvinyl alcohol hydrogel. Methods According to China national standardGB/T16886 documents, the toxicity of Evergel prosthetic nucleus materialwas investigated by the cytotoxicity test, sensitization test, haemolysis test,Ames test, mice marrow micronucleus test and chromosome aberration test ofmammalian cell in vitro. Results This material had no cytoxicity, no sen-sitivity, no obvious haemolysis, and no mutagencity in Ames test, micemarrow micronucleus test and chromosome aberration test of mammalian cellin vitro. Conclusion The Evergel prosthetic nucleus has a good biocom-patibility and can be used clinically.
