Expression of CEA,ICAM-1 on lymphatic endothelial cells in rectum cancer of human
- VernacularTitle:CEA,ICAM-1和CD31在人直肠癌淋巴管内皮细胞的表达
- Author:
Hua TIAN
;
Zhiyu LIU
;
Yao CHEN
;
Yunhai FANG
;
Ruixiang LI
;
Guibao LI
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Carofncerbryonlo antigen;
Cell adhesion molecules;
Gene CD31;
Endothelium,lymphatic
- From:
Chinese Journal of Current Advances in General Surgery
2004;7(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive:To study the expression of cell adhesion molecules on the lymphatic endothelial cells In the rectum cancer and peritumoral lymph nodes as well as their relationship with the diffusion of cancer cellS. Methods: In this Study the immunhistochemistry method was employed to observe the expression of CEA, ICAM-1 and CD31 on rectum cancer lymphatic endo-thelial cells. Results :The results demonstrated that CEA and lCAM-1 were highly expressed on the lynphatio endothelial cells in the peritumoral rectum tissues and lymph nodes. It was, howev-er,negative in normal lymphatic endothelial cells. CD31 was expressed on both lymphatic endothe-Ilal cells in the periturmral rectum tissues and lymph nodes and vessel endothelial cells of the normal human. Conelusion: The study suggests that there are relationships between the dis-semination of cancer cells and excession of CEA, lCAM-1 and CD31 in lymphatic endothelial cells.The CAE and ICAM-1 seem to induce stable adhesion between oancer cells and endothelial cells.
