The Effect of Hypertriglyceridemia on Vascular Endothelial Function
- VernacularTitle:高甘油三酯血症对血管内皮功能的影响
- Author:
Yun HUANG
;
Guizhu DAI
;
Zongchen FENG
;
Chengfa LU
;
Bei CHENG
;
Qiufen WANG
;
Fuding NIE
;
Jingdong LI
- Publication Type:Journal Article
- Keywords:
hypertriglyceridemia;
endothelium;
vasodilatation
- From:
Chinese Journal of Hypertension
2004;12(2):120-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hypert riglyceridemia on vascular endothelial function. Methods With high-resolution ultrasound, flow and nitroglycerin-induced dilatation of the brachial artery were determined in thirty hypertriglyceridemic patients and thirty healthy subjects as controls. Serum lipid and plasma endothelin (ET) were determined. Results In patients with hypertriglyceridemia,flow-induced vasodilatation was much reduced compared with that in the control subjects[(2.7±2.0)% vs (15.0±8.0)%, P<0.001］.However, vasodilatation in response to nitroglycerin were similar in both groups［(15.0±5.0)% vs (16.8±9.0)%, P>0.05].Plasma ET level in the hypertriglyceridemic group was significantly higher than that in the control group［(106.22±19.16) μg/L vs (72.37±14.06) μg/L, P<0.001].ConclusionEndothelium-dependent vasodilatation was impaired in patients with hypertriglyceridemia.
