Relation research of the expression and function of VEGF and its receptor
- VernacularTitle:血管内皮生长因子及其受体的表达与功能关系的研究
- Author:
Huafeng KANG
;
Xijing WANG
;
Xinghuan XUE
;
Xiaoxu LIU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2001;5(21):152-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective We studied the expression of VEGF and its receptor,FLK－ 1,in neuroblastoma and its relation to clinical features.Methods With the help of antigen repairing,immunohistochemical analysis using antibody against VEGF,FLK－ 1 was carried out on speciments of 52 cases of neuroblastoma.Results There were 36 cases of VEGF and 34 cases of FLK－ 1 positive expression,the expression of them were nearly consistent.The positive rate of VEGF and FLK－ 1 were higher in metastatic tumors(28/34,26/34)than in non－ metastastic tumors and had statistical significance(respectively P<0.01,P<0.05).The expression of VEGF in UH tumors was higher than in FH tumors,and statistical value is significant(P<0.05).Conclusion VEGF is a vital angiogenic factor,and may play an improtant role in the progression and metastasis of neuroblastoma.Its expression and function correlates well to FLK－ 1,and may aid in predicting patients at risk of metastasis.
