Vascular endothelial growth factor and its effect on bone formation
- VernacularTitle:血管内皮生长因子及其对成骨的影响
- Author:
Kai CAO
;
Hong AN
;
Dianming JIANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2005;9(2):248-251
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To review the outcomes of experiments about vascular endothelial growth factor(VEGF) and the effect of it on bone formation, and to make sure whether VEGF can promote bone formation or not.DATA SOURCES: Electronic data searches were performed to obtain data from the databases of http://www.ncbi. nlm. nih. gov/pubmed and http://www. zglckf.com. DATA SELECZION: Nearly 30 articles about VEGF and the role of VEGF affecting bone formation were selected, regardless of the randomized design,blind method involved in or not.DATA EXTRACTION: These researches proved the structures, biologic properties and expression of VEGF and vascular endothelial growth factor receptor(VEGFR), and showed that VEGF plays an important role in endochondral ossification by promoting angiogenesis, bone turnover and preventing apoptosis of chondrocyte. In intramembranous ossification, absence of cartilage, osteoblasts are likely producing, and responding to, VEGF. VEGF also acts to recruit and activate osteoclasts as well as stimulate osteoblast chemotaxis, differentiation and matrix mineralization. It is debatable whether local application of exogenous VEGF can promote bone repair or not. However, in certain situation such as ischemia, the increase of VEGF locally may promote bone repair.DATA SYNTHESIS: Compared with the control group, VEGF can promote osteogenesis, bone formation and remodeling through the effect of VEGF on endochondral ossification and intramembranous ossification.CONCLUSION: One possible advantage of local VEGF therapy may be its ability to couple angiogenesis with bone formation and remodeling. If we can ultimately apply VEGF to treat osteonecrosis, bone defect and nonunion, we will find a new therapy for these diseases.
