Antinociceptive effect of glucosides of Chaenomeles speciosa
- VernacularTitle:木瓜苷的镇痛作用
- Author:
Niping WANG
;
Min DAI
;
Hua WANG
;
Lingling ZHANG
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
analgesia test;
Chaenomeles speciosa;
glucoside;
dinoprostone;
tumor necrosis factor
- From:
Chinese Journal of Pharmacology and Toxicology
2005;19(3):169-174
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the antinociceptive effects of glucosides of Chaenomeles speciosa(GCS) and to study their relative mechanism. METHODS The effects of GCS on normal and inflammatory animals were observed in mouse acetic acid writhing test, mouse formalin test and arthritic flexion test of adjuvant arthritis(AA) rats; the concentration of prostaglandin E2 (PGE2) and tumor necrosis factor-α(TNF-α) secreted by the synovial cells of AA rats were measured by radioimmunoassay. RESULTSDifferent doses of GCS (60, 120, 240 mg·kg-1 for mice and 30, 60, 120 mg·kg-1 for rats, ig) inhibited mice′s writhing response and second phase of formalin response. It also suppressed the increased arthritic flexion scores in AA rats. On 28 d after inflammation induction, GCS (60, 120 mg·kg-1) decreased the concentration of PGE2 and TNF-α of synovial cells in the AA rats. CONCLUSIONGCS have antinociceptive effects, which related to its inhibitory effects on peripheral inflammatory mediators.
