Changes of Hippocampus Somatostatin and Learning Ability in Rats after+Gz Exposure
- VernacularTitle:+Gz暴露后大鼠海马生长抑素与学习能力的变化
- Author:
Xinsheng CAO
;
Xiqing SUN
;
Yanhong WU
;
Xingyu WU
;
Tingsong LIU
;
Shu ZHANG
- Publication Type:Journal Article
- Keywords:
positive acceleration;
+ Gz;
hippocampus;
learning ability;
somatostatin
- From:Space Medicine & Medical Engineering
2005;18(2):79-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate changes of learning ability and somatostatin (SS) changes after positive acceleration (+Gz) exposures. Mehtod Eighty male SD rats were randomly divided into 3groups: control group(Con), +6 Gz/3 min group ( +6 Gz), and +10 Gz/3 min group ( +10 Gz),8 rats in each group. Changes of learning ability in rats were observed at 0 d, 2 d, 4 d and 6 d after + Gz exposure. SS in hippocampus was measured by RIA at 0 d, 2 d and 4 d after + Gz exposures ( there were 8 rats every time, in each group). Result In Y-maze test,number of correct response decreased significantly (P ＜0.01 ), and total reaction time increased significantly(P ＜0.01 ) in +6Gz and +10 Gz groups as compared with control group; number of correct response and total reaction time in +10 Gz group changed significantly at 0 d(P ＜0.01 or P ＜0.05) as compared with +6Gz group. RIA showed that, content of SS in hippocampus declined at 0 d and 2 d(P ＜0.05 or P ＜0.01) in +6 Gz and + 10 Gz groups as compared with control group. Conclusion + Gz exposure could impair learning ability of rats, and inhibit expression of SS in hippocampus.
