Trend of research on late-onset Alzheimer disease and alpha 2-macroglobulin

VernacularTitle:晚发型阿尔茨海默病与α2巨球蛋白的研究动态
Author: Erhe XU ; Chunqiu FAN
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2005;9(5):164-164
CountryChina
Language:Chinese
Abstract: AIM: To investigate the relationship between Alzheimer disease(AD) and alpha 2-macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late-onset AD.METHODS: The significance of α2M in the late-onset AD was revealed through pathology of α2M in AD and the polymorphism of α2M in AD patients.RESULTS: The association between AD and α2M region on the twelfth chromatosome was analyzed with the genic linkage, and pathological symptom of α2M in AD patients was supported by many evidences. Two polymorphism sites of α2M were located on the 12P12-13, which could increase more risks to AD patients.CONCLUSION: It is significant to investigate the frequency, mutation,polymorphism and expression of gene α2M for the pathogenesis of late-onset AD and its genic diagnosis.