Effects of ferulic acid on E-selectin expression in activated endothelial cell and leukocyte-endothelial cell adhesion
- VernacularTitle:阿魏酸对活化内皮细胞E-选择素表达及内皮与白细胞粘附的影响
- Author:
Xiaolan WANG
;
Xiaohui HU
;
Mingen Lü
;
Zhenlun GU
;
Changgeng RUAN
- Publication Type:Journal Article
- Keywords:
ferulic acid;
endothelial cell;
E-selectin;
adhesion
- From:
Acta Pharmaceutica Sinica
2005;40(5):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of ferulic acid (FA) on E-selectin expression in human umbilical vein endothelial cells (HUVECs) activated by lipopolysaccharide and leukocyte-endothelial cell adhesion. Methods The effects of FA on E-selectin and E-selectin mRNA expression were determined by flow cytometry and reverse transcription polymerase chain reaction. The effect of FA on HL60-HUVEC adhesion was evaluated with the method of staining the cells by Rose Bengal. Results The expression of tively). Conclusion FA can inhibit the expression of E-selectin and E-selectin mRNA and HL60-HUVEC adhesion. This may contribute to its protective effect against ischemia-reperfusion injury.
