pCREB IN GLUTAMATE CONTAINING NEURONS GREATLY UPREGULATED IN RAT AMYGDALA AFTER A STRESS BY FORCED SWIMMING
- VernacularTitle:强迫游泳后大鼠杏仁体中谷氨酸神经元中的pCREB水平显著上调
- Author:
Lu GAO
;
Ruixi LI
;
Jie WANG
;
Zhongliang DING
;
Yuwen PENG
- Publication Type:Journal Article
- Keywords:
pCREB;
glutamate;
parvalbumin;
forced swimming;
double staining;
amygdala;
rat
- From:
Chinese Journal of Neuroanatomy
2005;21(5):463-470
- CountryChina
- Language:Chinese
-
Abstract:
Amygdala (AM) plays crucial roles in emotional learning, memory and behavior. These functions of AM are carried out by three main subnuclei (lateral nucleus, basolateral nucleus and central nucleus) in AM and closely related with a transcription factor, cAMP- responsive element binding protein (CREB) in the neurons of the AM. CREB can be phosphorylated (pCREB) in many kinds of neuronal processes to regulate the synthesis of proteins for the formation of memory processes. In order to identify what neuronal types express pCREB and how the pCREB levels changed at different time intervals after an emotional stress stimulation, the present study is designed to investigate pCREB-, glutamate (Glu)- and parvalbumin (PV)- immunoreactive (IR) profiles in AM and the levels of pCREB in AM after a stress of forced swimming (FS). The results showed that the pCREB expressed in the Glu-IR neurons but not in the PV-IR neurons, and the expression level of the pCREB increased dramatically after the stress. The present results suggested that pCREB modulates the emotional processes through the Glu-IR neurons and that the pCREB greatly upregulated to response to the emotional stimuli.
