Three Cases of Allopurinol Hypersensitivity Syndrome.
- Author:
Hyeong Don BANG
;
Jin Ho CHUNG
;
Kwang Hyun CHO
;
Jai Il YOUN
- Publication Type:Case Report
- Keywords:
Allopurinol Hypersensitivity Syndrome
- MeSH:
Abnormalities, Multiple;
Allopurinol*;
Exanthema;
Fever;
Hospitalization;
Humans;
Hypersensitivity*;
Leukocytosis;
Skin
- From:Korean Journal of Dermatology
1995;33(1):130-134
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The allopurinol hypersensicivity syndrome is a rare, but life thereaning immunologic reaction of allopurinol therapy, characterized by multiple abnormalities such as fever, rash, decreased renal function, hepatocellular injury, leukocytosis, and eosinophila. It may require prolonged hospitalization and occasionally involves residual morbidity. Three patients developed erythematous skin eruption three to five weeks after beginning therapy with allopurinol. The clinical, laboratory, and histologic findings of these patients were compatible with a allopurinol hyperensitivity syndrome.
