Effect of mifepristone on the expression of tumor necrosis factor-α and transforming growth factor-β in decidua of early pregnancy
- VernacularTitle:米非司酮对早孕蜕膜肿瘤坏死因子-α及转化生长因子-β表达的影响
- Author:
Jing ZHANG
;
Enju XIA
;
Jianguo ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Obstetrics and Gynecology
2001;36(1):27-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of mifepristone on the expression of tumor necrosis factor-α（TNF-α） and transforming growth factor-β（TGF-β）in decidua of early pregnancy. Methods Thirty artificial abortion women as control and thirty drug abortion women were enrolled for study. The expressions of TNF-α and TGF-β in decidua were measured with immunohistochemical method. Results There was no significant difference of TNF-α positive expression rates between drug abortion group (73.33%) and artificial abortion group (70.00%，P>0.05). TGF-β expression rate of drug abortion group was similar to that of artificial abortion group. The highly-positive (+ + and + + +) TNF-α expression rate in drug abortion group was significantly higher than that in artificial abortion group (P<0.05). TGF-β expression degree in decidua of drug abortion group was significantly lower than that of artificial abortion group (P<0.05). The ratio of TNF-α/TGF-β in drug abortion group is higher than that in artificial abortion group. Conclusion TGF-β has great effect on regulating the embryo development of early pregnancy. The change of TNF-α may be the reason of abortion. Mifepristone may interfere with embryo growth by inhibiting the activity of TGF-β or by stimulating the secretion of TNF-α.
