Contrast-enhanced MRA of pulmonary artery combined with pulmonary perfusion imaging in pigs: a comparative study with DSA
- VernacularTitle:Gd-DTPA磁共振肺灌注成像对猪肺动脉栓塞的诊断价值
- Author:
Shiyuan LIU
;
Weihua DONG
;
Xiangsheng XIAO
;
Yun FENG
;
Chunshan YANG
;
Xueyuan XU
;
Chenshi ZHANG
;
Chengzhou LI
;
Huimin LI
;
Yuli LI
- Publication Type:Journal Article
- Keywords:
magnetic resonance angiography;
angiography,digital subtraction;
pulmonary embolism;
diagnosis
- From:
Academic Journal of Second Military Medical University
2005;26(7):743-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the injection protocol of contrast medium for contrast-enhanced MRA (CEMRA) of pulmonary artery and to evaluate the diagnostic value of CEMRA and pulmonary perfusion imaging (PPI) in an experimental model of acute pulmonary embolism. Methods:CEMRA and PPI were performed in 6 normal pigs with different doses of gadolinium contrast agent (5ml, 10ml, 15ml, 20ml and 25ml) at an injection rate of 3ml/s, and 3 pulmonary embolism models were injected with 20 ml contrast agent at 3 ml/s. DSA was also performed for comparison. Results:The signal intensities and the signal to noise ratios of the pulmonary arteries kept increasing with the dose increase of the contrast agent, but the best angio-pulmonary contrast dose was 10-15ml (0.25-0.375mmol/kg), while the optimal dose for PPI was 15-20ml (0.375-0.5mmol/kg). Although CEMRA demonstrated less obstructed pulmonary arteries than DSA (5/10 vs 8/10)did, it detected all obstructions when combined with PPI. The pulmonary infarction zones showed wedge-shaped perfusion defects on the PPI images, with the signal intensities lower than those of the normal areas (137.86±45.32 vs 330.14±46.52, P<0.001). Conclusion:It is suggested that the optimal dose of the contrast agent is 0.25mmol/kg to 0.375mmol/kg for CEMRA, and 0.375mmol/kg to 0.5mmol/kg for lung perfusion. CEMRA combined with PPI may be better than DSA in demonstrating pulmonary embolism.
