Evaluation of tissue doppler echocardiography on detecting early myocardial relaxation abnormality in adriamycin-induced cardiomyopathy rabbits
- VernacularTitle:组织多普勒超声评价阿霉素诱导兔心肌病早期松弛功能改变的实验研究
- Author:
Hongwen FEI
;
Xinfang WANG
;
Mingxing XIE
;
Yale HE
- Publication Type:Journal Article
- Keywords:
echocardiography;
rabbit;
adiamycin;
cardiomyopathy;
tissue Doppler imaging
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2005;10(7):738-742
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate myocardial relaxation function changes in an adriamycin-induced cardiomyopathy model using the transmitral flow velocity to mitral annular velocity ratio (E/E'), a strong positive relationship with left ventricular filling pressure and a good indicator for evaluating left ventricular diastolic relaxation abnormality. METHODS: Twenty-eight Japanese rabbits were divided into two groups. Adriamycin was administered at cardiomyopathy model. 8 rabbits served as controls receiving the same amount of saline once a week for a total of 8 weeks. Conventional and tissue Doppler echocardiography (TDE) were performed at baseline, 4th, 6th,8th, 10th and 12th week. RESULTS: In the adriamycin-treated group, LV chamber diameter significantly increased, while ejection fraction and fraction shortening significantly decreased in 10th and 12th week (P ＜0.05). The significant changes were firstly found in 10th week. Mitral annulus systolic peak velocity (S') by TDE significantly decreased in 8th, 10th and 12th week ( P ＜0.05). The significant changes were firstly found in 8th week. The ratio of E/E' significantly increased in 6th,8th, 10th and 12th week (P ＜ 0.05). The significant changes were firstly found in 6th week. In the control group, no significant changes were found in all parameter by tissue Doppler conventional echocardiography (P ＞0.05). CONCLUSION: Myocardial function is reduced in adriamycin-induced rabbit model of dilated cardiomyopathy. The relaxation parameter (E/E') by TDE changes is earlier than contraction indices S' by TDE and conventional echocardiography in adriamycin-induced cardiomyopathy rabbits, which provides a new sensitive and reliable method to evaluate LV relaxation function.
