The Value of Brain Natriuretic Peptide to Predict Short-term Cardiac Death in Patients with Cardiovascular Disease
- VernacularTitle:脑钠肽对心血管病患者近期心源性死亡的预测价值
- Author:
Tongwen SUN
;
Yanzhou ZHANG
;
Li LI
;
Chunguang QIU
;
Zhenwen HUANG
;
Lexin WANG
- Publication Type:Journal Article
- Keywords:
Brain natriuretic peptide;
Cardiovascular disease;
Cardiac death
- From:
Chinese Journal of Hypertension
2005;13(6):348-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective Brain natriuretic peptide(BNP) is released from the cardiac ventricles in response to increased wall tension. The prognostic significance of blood brain natriuretic peptide in Chinese patients with cardiovascular disease has not been established. The purpose of this study was to investigate the value of brain natriuretic peptide for predictin g cardiac death within 1 month in Chinese patients with cardiovascular disease. Methods One hundred and seven inpatients with cardiovascular disease, whose blood brain natriuretic peptide concentration were measured within 1 - 3 days of admission, using triage BNP test, were divided into 2 groups: the survival and the non-survival, according to the results of 1was positively correlated with heart rate, left ventricular end-diastolic dimension, history of heart failure and old myocardial infarction (r=0.28, P=0. 000 4; r=0.49, P＜0. 000 5; r=0.39, P＜0. 000 5; r=Area under the curve of the receiver-operating-characteristic(ROC) of brain natriuretic peptide to predict cardiac death at 1 month in patients with cardiovascular disease was 0.89%, 95% confidence interval 0.79-0. 98, P＜0. 000 5; stepwise logistic regression analysis indicated that brain natriuretic peptide (≥755pg/mL) was the only independent predictor of cardiac death at 1 month in patients with cardiovascular disease (OR= 17.6, 95 % confidence interval, 8.7- 66.5, P＜0. 000 5 ). Conclusion Brain natriuretic peptide might predict cardiac death at 1 month in patients with cardiovascular disease.
