Enhancement of systemic and CNS delivery of meptazinol hydrochloride by intranasal administration to rats
- VernacularTitle:鼻腔给药促进盐酸美普他酚在大鼠体内的吸收及脑转运
- Author:
Zhenqi SHI
;
Qizhi ZHANG
;
Xinguo JIANG
- Publication Type:Journal Article
- Keywords:
intranasal administration;
meptazinol hydrochloride;
cerebrospinal fluid;
rats
- From:
Acta Pharmaceutica Sinica
2005;40(8):754-757
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the extent of systemic absorption and uptake of meptazinol (MEP) hydrochloride in cerebrospinal fluid (CSF) after intranasal administration on rats and compare with oral administration. Methods CSF samples were collected by a serial sampling method. The concentration of MEP in the biological samples was measured by HPLC with fluorescence detector. Results Rapid and significant levels of MEP in plasma and CSF can be achieved after nasal administration whereas the oral administration resulted in considerably lower drug concentrations. AUC in plasma and CSF from the nasal route are 7.375 and 15.6 folds compared with those of the oral route, respectively. Conclusion Intranasal MEP is able to show quick absorption and improve the bioavailability, which could be a promising alternative to oral administration.
