Pharmacogenetics of anesthetics.
10.4097/kjae.2008.55.5.527
- Author:
Kye Min KIM
1
Author Information
1. Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. kyemin@paik.ac.kr
- Publication Type:Review
- Keywords:
anesthetics;
pharmacogenetics
- MeSH:
Analgesics;
Anesthetics;
Genetic Variation;
Pharmacogenetics
- From:Korean Journal of Anesthesiology
2008;55(5):527-537
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Genetic and/or environmental factors lead to large inter-individual variability in the efficacy and the side effects of drugs. Pharmacogenetics is the study of genetically determined differences in drug response. It focuses on the genetic variations involved in drug metabolism, transporters and receptors, which result in the pharmacokinetic and pharmacodynamic differences. Recently, pharmacogenetic studies on anesthetics and analgesics have been carried out actively. The pharmacogenetics of the commonly used drugs in anesthetic practice is reviewed.
