Changes of regional cerebral blood flow in acquired immunodeficiency syndromes without chronic brain syndrome
- VernacularTitle:无痴呆综合征艾滋病患者局部脑血流的变化
- Author:
Qiulian WU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2005;9(13):218-219
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND: Reduced cortico-subcortical regional cerebral blood flow (rCBF) in patients with acquired immunodeficiency syndromes(AIDS) was found. However, the changes of rCBF in AIDS patients without chronic brain syndrome still remain unclear.OBJECTIVE: To investigate the changes of rCBF in AIDS patients without chronic brain syndrome by using 99Tcm-ECD cerebral single photon emission computerized tomography(SPECT) in order to provide imaging evidence for primary rehabilitative prevention, early intervention and occurrence of dementia in AIDS patients without chronic brain syndrome.DESIGN: Observational comparative study based on AIDS patients without chronic brain syndrome and healthy people as the controls.SETTING: Nuclear medical department in a university hospital.PARTICIPANTS: Four Chinese(Cantonese) male AIDS patients, between 31 and 36 years old(mean age of 34) without chronic brain syndrome, were selected from the First Affiliated Hospital of Jinan University from February to July 1999. Sixteen healthy males, with an age from 21 to 48 years(mean 37 years), were selected from the First Affiliated Hospital of Jinan University as the control group from February 1999 to June 2000.METHODS: 99Tcm-L, L-ethlcysteinate dimmer (99Tcm-ECD) brain SPECT imaging was performed on AIDS patients without chronic brain syndrome and healthy controls. Image data were acquired with two-head SPECT. The rCBF was calculated with a semi-quantitative processing software. And the changes of rCBF were compared between the two groups.MAIN OUTCOME MEASURES: Comparison of the semi-quantitative processing results of rCBF between the two groups.RESULTS: The rCBF in the right and left frontal, vertex, temporal lobe,basal ganglia, thalamus, gyrus rectus and pons were decreased significantly in the four AIDS patients without chronic brain syndrome than those of the normal control group( t =3.53 -9.37, P ＜ 0.01).CONCLUSION: Reduced cortico-subcortical rCBF in AIDS patients without chronic brain syndrome is observed with SPECT, and this provides imaging evidence for early intervention and the occurrence of dementia in AIDS patients without chronic brain syndrome.
