Comparison of 6 microelements in hair between schizophrenic patients and normal persons
- VernacularTitle:精神分裂症患者与正常人头发中6种微量元素的差异比较
- Author:
Quansheng TANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2005;9(20):246-248
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND: It has been testified the interrelation between many microelements and mental diseases by determination of serum concentration or single determination of several microelements. But there are lack of definite data in comparison between big samples and various microelements.OBJECTIVE: To determine the levels of 6 microelements (Pb, Cd, Al, Zn, Cr and Ni) in hair of schizophrenic patients and compare with normal persons.DESIGN: Case-control, single center and big sample observation was designed.SETTING: Department of Psychiatry, Nanning Fifth People's Hospital.PARTICIPANTS: Totally 440 cases of latest inpatients of schizophrenia were selected from the ward of Department of Psychiatry, Nanning Fifth People's Hospital from April to December in 2000. They had not taken drugs for anti-mental disease yet, of which, 260 cases were male, 180 cases female; aged averagely (34±13) years, 122 cases ≤ 29 years old, 236 cases aged varied from 30 to 49 years and 82 cases ≥50 years old. In the control group, 218 persons were selected from the staffs of Nanning Fifth People's Hospital, of which, 128 cases were male and 90 cases female; aged averagely (37±11) years, 56 cases ≤ 29 years old, 121 cases aged varied from 30 to 49 years and 41 cases ≥50 years old. All of the participants were in the know and agreed with the experiment.METHODS: WFX-12 type atomic absorption spectrophotometer was used to determine in parallelism the levels of Pb, Cd, Al, Zn, Cr and Ni in hair of 440 cases of schizophrenic patients and 218 cases of normal persons.Multi-factor logistic regressive model analysis was carried out on microelement levels between patient group and normal group.ment levels in hair concerning to sex and age among schizophrenic papatients and normal persons.RESULTS: Totally 440 cases of schizophrenia and 218 normal persons enanalysis: The odds ratios (OR) were 1.07, 0.32, 0.99, 0.99, 1.74 and 0.63 successively between schizophrenia and the levels of Pb, Cd, Al, Zn, Cr and Ni;mong schizophrenic patients: The levels of Cd and Zn in hair of male patients were higher than those of females [(0.46±0.40) μg/g, (0.33±0.27) μg/g;(128.40±38.95) μg/g, (118.95±35.67) μg/g, F=14.84, 6.71, P ≤ 0.01].The levels of microelements of patients at 3 different age divisions were tween schizophrenic patients and normal persons: The levels of Pb and Cr in hair of schizophrenic patients were higher than those in the control group[(10.22±7.79) μg/g, (8.44±7.57) μg/g;(1.36±0.71 μg/g, (1.18±0.46) μg/g,F=6.21-8.52, P ≤ 0.01], but the levels of Cd, Zn and Ni were lower than those in the control group [(0.41±0.36) μg/g, (0.51±0.40) μg/g;(124.53±37.89) μg/g, (139.21±34.52) μg/g;(0.90±0.66) μg/g,(1.05±0.53) μg/g, F=6.21-8.52, P ≤ 0.01].CONCLUSION: A certain of correlation presents between the levels of Pb, Cd, Al, Zn, Cr and Ni in hair and schizophrenia. The levels of Cd and Zn are different concerning to sex, in which, those of male were higher than female. The difference was not significant in the levels of 6 microelements concerning to age in patient group. The levels of Pb and Cr in hair of schizophrenia were higher than the normal persons, but the levels of Cd, Zn and Ni were lower than the normal persons.
