Dialectical cognition of free radical-induced aging theory
- VernacularTitle:自由基伤害衰老学说的辩证认识
- Author:
Dazhong YIN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2005;9(19):229-231
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE: Differential cognition and evaluation of the scientific merit of free radical-induced aging theory in the explanation of aging mechanism.DATA SOURCES: Literatures about free radical-induced aging theory were searched in Medline and Embase by computer from April 1976 to October 2004 with searching words of "free radical, aging, dialectical" and the language of the articles was limited in English, the subjects were the elderly and aging animal.STUDY SELECTION: To select literatures about free radical-induced aging theory for preliminary examines. Quality evaluation mainly examined the authenticity of the data, whether the survey design was rigorous, whether the intervention process was strict, and whether statistical management was reasonable.DATA EXTRACTION: A total of 30 articles about the merit of free radical-induced aging theory in the explanation of aging mechanism were searched, of which 18 experiments were in accorded with the inclusive criteria. In the 12 excluded experiments, 7 articles were the repetitions of same study, and 5 articles were Meta analytic study.DATA SYNTHESIS: Comparative analysis was conducted in the experimental results of aging essence and the prolongation of maximum duration of life explained by free radical-induced aging theory.CONCLUSION: Free radical-induced aging theory has an important biomedical academic merit, but it does not successfully explain the fundamental reason of agingand the essence of aging process.
