Mechanism of scarless healing of embryonic skin
- VernacularTitle:胚胎皮肤无瘢痕愈合机制研究进展
- Author:
Jun QIU
;
Jihong ZHOU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2005;9(22):228-230
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: Post-traumatic healing style is an important link in the process of wound healing. Scarless healing of fetus skin after trauma is the ideal healing style that is hunted for by people. The results of studies on the mechanism of scarless healing were reviewed to explore the mechanism of scarless healing of fetus skin.DATA SOURCES: Computer was applied to retrieve Medline database on the articles relating to the mechanism of scarless healing of fetus skin from January 1970 to December 2003. Docuterms were "fetus, skin and scarless healing". Language in the articles was limited to English.STUDY SELECTION: The documents were examined at first to exclude the study on non-healing mechanism. Full texts were found in the surplus documents. The inclusive criterion was the foundational experiment on the mechanism of scarless healing. Clinical trial and phenomenal study on scarless healing were excluded.DATA EXTRACTION: Forty-eight articles on experimental study relating to embryonic scarless healing were collected in all. Sixteen experiments accorded with the inclusive criterion and 32 were excluded.DATA SYNTHESIS: Sixteen experiments discussed the relationship between the fetus and scarless healing on terms of growth environment, inflammation reaction to trauma and regulation of fibroblast in organism, extracellular matrix and nany cellular factors.CONCLUSION: Growth environment of fetus has not so much relationship with the mechanism of scarless healing after trauma. Low reaction of fetus to inflammation, different extracellular matrix, component of collagen fiber and cell factors may take part in scarless healing process. Regulation of gene expression may play an important role in the process. But the concrete mechanism of scarless healing is not clear yet and still needs more researches and elucidations.
