No mutation was detected in the LMNA gene among sporadic Charcot-Marie-Tooth patients
- VernacularTitle:在散发型腓骨肌萎缩症患者中未检测出LMNA基因突变
- Author:
Shujuan SONG
;
Yuanzhi ZHANG
;
Biao CHEN
;
Manjie WANG
;
Yueying WANG
;
Yuanjin ZHANG
;
Ming YAN
;
Nanbert ZHONG
- Publication Type:Journal Article
- Keywords:
Charcot-Marie-Tooth disease;
Genes,LMNA;
Mutation
- From:
Journal of Peking University(Health Sciences)
2006;38(1):78-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To intensively investigate sporadic CMT patients, we have analyzed the LMNA gene in this study in a series of 32 unrelated CMT patients. Methods: Twelve exons of the LMNA gene were amplified from genetomic DNA. PCR products of each exon were analyzed by single strand conformational polymorphism (SSCP). Results: No abnormal SSCP pattern, suggesting no mutation in our CMT patients, was detected. Conclusion: The CMT diseases resulted from the mutations of LMNA gene were rare.
