Study of Gray Matter Loss in Alzheimer's Disease Based on Automatic Voxel-based Morphometry
- VernacularTitle:应用全脑逐像素形态学自动分析方法研究阿尔茨海默氏病的灰质缺失
- Author:
Bin YAN
;
Wei WANG
;
Hua LIU
;
Kuncheng LI
;
Ke LI
;
Baoci SHAN
;
Xiaowei TANG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease(AD);
magnetic resonance imaging(MRI);
regions of interest method;
voxel-based morphometry
- From:Space Medicine & Medical Engineering
2006;19(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the gray matter loss of Alzheimer's disease (AD) patients by processing the magnetic resonance imaging (MRI) with computer. Method A voxel-based morphometry (VBM) method was applied in this study. Result Bilateral loss of gray matter in AD patients was found in the entorhinal/ hippocampal/parahippocampal cortex areas, amygdala, the head of the caudate nucleus, middle temporal gyrus, cingulate gyrus, inferior parietal lobule, insula and dorsolateral prefrontal cortex. Furthermore, area of right pulvinar, cortex of superior temporal gyrus and superior parietal lobule reduced significantly. On the other hand, somatosensory/motor cortex, cerebellum and occipital lobe were relatively intact. Conclusion VBM overcomes the shortcomings of region of interesting(ROI), such as time-consuming, dependence on observer, and poorly reproducible, and can analyze the gray matter loss objectively and automatically and have a good perspective for clinical applications.
