Research progress on molecular pathology of cholangiocarcinoma
10.3760/cma.j.issn.1007-8118.2011.02.031
- VernacularTitle:胆管癌分子病理学研究进展
- Author:
Jing GUO
;
Jiye LI
- Publication Type:Journal Article
- Keywords:
Cholangiocarcinoma;
Molecular pathology;
Biliary epithelium
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(2):171-174
- CountryChina
- Language:Chinese
-
Abstract:
The early diagnosis of cholangiocarcinoma is difficult, and the prognosis is poor. The molecular mechanisms underlying the development, growth and metastatic spread of biliary tract cancers are still unclear. The increase in worldwide incidence and mortality of cholangiocarcinoma justifies the impellent need to clarify the intracellular mechanisms triggering the malignant transformation of the biliary epithelium and growth of biliary malignancies. A more complete characterization of the molecular pathology of bile duct cancers could lead to the identification of valid targets for diagnosis and therapy of these devastating malignancies. This review describes the scientific progress made over the past years with regard to the understanding of the molecular processes of cholangiocarcinogenesis.
